The lox we are the streets edited
Parkinson's disease (PD) is a progressive CNS disorder characterized behaviorally by motor impairment and neurochemically by a loss of nigrostriatal dopaminergic tone. Taken together, these data provide the first evidence that: (i) LOX isozymes are involved in the maintenance of normal dopaminergic function in the striatum, and (ii) the 5- and 12/15-LOX isozymes contribute differentially to striatal vulnerability in response to neurotoxicant challenge. In na ve null 12/15-LOX mice, no significant change in striatal DA values was observed compared to WT, and following MPTP treatment, the transgenics revealed striatal DA reduction similar to the challenged WT mice. In contrast, null 5-LOX littermates demonstrated no significant striatal DA depletion or astrogliosis (as noted by Western blot analyses for GFAP immunoreactivity). When challenged with the selective dopaminergic toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), WT mice showed marked reduction in DA (31.9%) and robust astrocytic and microglial activation as compared to saline-treated animals. WT mice (26.2%) however, no changes in levels of DA or TH immunoreactivity were observed in null 12/15-LOX vs. A concomitant decline in striatal tyrosine hydroxylase (TH) enzyme was also revealed in null 5-LOX vs. wildtype (WT)) in striatal dopamine (DA) was detected (n=6-8 per genotype). In na ve mice deficient in 5-LOX expression, a modest but significant reduction (18.0% reduction vs. To determine whether the isozymes contribute differently to nigrostriatal vulnerability, the effects of 5- and 12/15-LOX deficiency on dopaminergic tone under na ve and toxicant-challenged conditions were tested. These LOX isozymes are distinct in function, with differential effects on neuroinflammation, and the impact of the distinct isozymes in the pathogenesis of Parkinson's disease (PD) has not as yet been evaluated. Duh, Jadakiss aired everyone out on this one) 5/5ģ "Can I Live" 4:10 (Styles P and Sheek are neck for neck on this, Sheek is just ill & Styles is deep on this with the bars) 5/5ĥ "Breathe Easy" 4:08 (Classic, Sheek is crazy on this) 5/5Ħ "Felony Niggas" ( Styles P solo) 3:59 (Hard.) 4.5/5ħ "Wild Out" 5:27 (Jada Bodied this one listen to his last bars.wow.) 4/5Ĩ "Blood Pressure" ( Jadakiss solo) 3:46 (This track separated Kiss from the pack) 5/5ĩ " Recognize" 4:13 (Classic Premier, Styles P drops a deep verse) 5/5ġ1 "Y'all Fucked Up Now" 4:30 (Another hard track, Sheek Bodies the track) 4.5/5ġ2 "Scream L.O.X." 3:51 ("I show up to ya wedding rocking a white t, ya wife like ohh wee!" chill ass track) 4.5/5ġ3 "U Told Me" 4:53 (HARD!!!!!!!!! They all come through on here, it's a tough call) 5/5ġ5 " Ryde or Die, Bitch" 4:49 (Timbaland Provides a banger, Sheek has the best verse on here, Jada's "Pee in the bed" line was nice though) 4/5ġ6 "Bring It On" ( Sheek Louch solo) 4:45 (Could've been better) 3.The 5- and 12/15- lipoxygenase (LOX) isozymes have been implicated to contribute to disease development in CNS disorders such as Alzheimer's disease. I don't know why it's been 12 years and there's still no new lp out.
One of the hardest albums ever recorded, album is 4 stars off the bars alone.